Phase 1/2 Clinical Trial of CP-506 (HAP) in Monotherapy or With Carboplatin or ICI

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

126

Participants

Timeline

Start Date

May 30, 2023

Primary Completion Date

February 28, 2027

Study Completion Date

May 31, 2027

Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
DRUG

CP-506

CP-506 is a hypoxia-activated DNA alkylating agent specifically designed to have a bystander effect, aqueous solubility, oral bioavailability, and no off-mechanism activation by the human aerobic reductase AKR1C3

DRUG

Carboplatin

Antineoplastic agent, ATC Code: LO1X A02

DRUG

Immune checkpoint inhibitor

Drug that blocks immune checkpoint proteins: PD-1, PD-L1, CTLA-4

Trial Locations (5)

9000

NOT_YET_RECRUITING

UZ Gent, Ghent

Unknown

NOT_YET_RECRUITING

Institut Jules Bordet, Brussels

RECRUITING

Erasmus MC, Rotterdam

6229HX

RECRUITING

Academisch Ziekenhuis Maastricht (Leading Centre), Maastricht

08035

NOT_YET_RECRUITING

Institut Vall d'Hebron, Barcelona

All Listed Sponsors
collaborator

Erasmus Medical Center

OTHER

collaborator

Jules Bordet Institute

OTHER

collaborator

Academisch Ziekenhuis Maastricht

OTHER

collaborator

Vall d'Hebron Institute of Oncology

OTHER

collaborator

University Ghent

OTHER

lead

Maastricht University Medical Center

OTHER