Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis

NACompletedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

September 17, 2021

Primary Completion Date

September 30, 2023

Study Completion Date

September 30, 2023

Conditions
Amyotrophic Lateral Sclerosis
Interventions
OTHER

Measure of visual acuity

ETDRS and Parinaud scale

OTHER

Interferometry

Non-contact exam measuring N.I.B.U.T (Non-invasive break-up time), quantitative and qualitative evaluation of the meibomian glands and quantitative evaluation of the tear meniscus

OTHER

Samples of basal tears

Collection of basal tears without instillation of anesthetic with a Schirmer strip for 5 minutes and by microcapillary

OTHER

Central corneal sensitivity

Central corneal sensitivity using a Cochet-Bonnet esthesiometer (Luneau©)

OTHER

Slit lamp examination and undilated fundus

Slit lamp examination and undilated fundus

OTHER

Conjunctival impression

Conjunctival impression with anesthetic instillation

OTHER

Evaluation of the corneal innervation

Contact corneal confocal microscopy

Trial Locations (3)

37000

Ophthalmology Department, University Hospital of Tours, France, Tours

37044

Neurology Department, University Hospital of Tours, France, Tours

Unknown

Centre d'Investigation Clinique_CIC 1415, Tours

All Listed Sponsors
lead

University Hospital, Tours

OTHER

NCT04953286 - Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis | Biotech Hunter | Biotech Hunter