NCT04952753 - Study of NIS793 and Other Novel Investigational Combinations With SOC Anti-cancer Therapy for the 2L Treatment of mCRC | Biotech Hunter

Enrollment

204

Participants

Timeline

Start Date

November 15, 2021

Primary Completion Date

January 20, 2025

Study Completion Date

January 20, 2025

Conditions

Metastatic Colorectal Cancer

Interventions

DRUG

NIS793

Investigational drug NIS793 will be administered intravenously (IV) at the dose and schedule determined in the safety run-in part.

DRUG

Bevacizumab

Bevacizumab will be administered IV

DRUG

Modified FOLFOX6

5-fluorouracil \[continuous infusion\], leucovorin \[administered IV\] (or levoleucovorin \[administered IV\]), and oxaliplatin \[administered IV\]

DRUG

FOLFIRI

5-fluorouracil \[continuous infusion\], leucovorin \[administered IV\] (or levoleucovorin \[administered IV\]), and irinotecan \[administered IV\]

DRUG

Tislelizumab

Investigational drug tislelizumab will be administered intravenously (IV).

Trial Locations (55)

1000

Novartis Investigative Site, Brussels

1200

Novartis Investigative Site, Brussels

3000

Novartis Investigative Site, Leuven

3550

Novartis Investigative Site, Bendigo

5000

Novartis Investigative Site, Adelaide

6009

Novartis Investigative Site, Perth

9007

Novartis Investigative Site, Sankt Gallen

10002

Novartis Investigative Site, Taipei

13353

Novartis Investigative Site, Berlin

20089

Novartis Investigative Site, Rozzano

20133

Novartis Investigative Site, Milan

20162

Novartis Investigative Site, Milan

20249

Novartis Investigative Site, Hamburg

28040

Novartis Investigative Site, Madrid

37203

Sarah Cannon Research Institute, Nashville

39008

Novartis Investigative Site, Santander

44093

Novartis Investigative Site, Nantes

44791

Novartis Investigative Site, Bochum

45147

Novartis Investigative Site, Essen

60488

Novartis Investigative Site, Frankfurt am Main

63110

WA Uni School Of Med, St Louis

70403

Novartis Investigative Site, Tainan City

77030

Uni Of TX MD Anderson Cancer Cntr, Houston

78229

Mays Cancer Center, San Antonio

84082

Novartis Investigative Site, Avignon

89081

Novartis Investigative Site, Ulm

90025

The Angeles Clinic and Research Institute, Los Angeles

94010

Novartis Investigative Site, Créteil

119074

Novartis Investigative Site, Singapore

3109601

Novartis Investigative Site, Haifa

4941492

Novartis Investigative Site, Petah Tikva

48109-0331

University of Michigan Medical, Ann Arbor

08816

Astera Cancer Center, East Brunswick

L6R 3J7

Novartis Investigative Site, Brampton

N1R 3G2

Novartis Investigative Site, Cambridge

H2W 1T8

Novartis Investigative Site, Montreal

H3T 1E2

Novartis Investigative Site, Montreal

656 53

Novartis Investigative Site, Brno

500 05

Novartis Investigative Site, Hradec Králové

140 59

Novartis Investigative Site, Prague

01307

Novartis Investigative Site, Dresden

Unknown

Novartis Investigative Site, Pokfulam

Novartis Investigative Site, Shatin

464 8681

Novartis Investigative Site, Nagoya

277 8577

Novartis Investigative Site, Kashiwa

216-8511

Novartis Investigative Site, Kawasaki

541-8567

Novartis Investigative Site, Osaka

930-0194

Novartis Investigative Site, Toyama

05505

Novartis Investigative Site, Seoul

08208

Novartis Investigative Site, Sabadell

08035

Novartis Investigative Site, Barcelona

08036

Novartis Investigative Site, Barcelona

AB25 2ZN

Novartis Investigative Site, Aberdeen

CB2 0QQ

Novartis Investigative Site, Cambridge

OX3 7LE

Novartis Investigative Site, Oxford