Phase-2 Dacomitinib Study on Patients With EGFR-Driven Advanced Solid Tumours With Low EGFR-AS1 IncRNA Expr or Other Novel Emerging Biomarkers

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

August 24, 2021

Primary Completion Date

April 30, 2027

Study Completion Date

May 31, 2027

Conditions
Advanced Solid TumoursNon-small Cell Lung CancerHead and Neck Squamous Cell Carcinoma
Interventions
DRUG

Oral Dacomitinib

All subjects will receive the open-label Dacomitinib as tablets for oral self-administration on a continuous daily basis at a dose of 30 mg for one cycle. For subjects eligible for dose titration after Cycle 1, and after shared patient and investigator decision, these subjects will receive Dacomitinib 45 mg orally on a continuous daily basis.

Trial Locations (2)

119074

National University Cancer Institute, Singapore, Singapore

169610

National Cancer Centre Singapore, Singapore

All Listed Sponsors
collaborator

Singapore Translational Cancer Consortium

UNKNOWN

collaborator

Cancer Science Institute of Singapore

UNKNOWN

collaborator

Genome Institute of Singapore

OTHER

lead

National Cancer Centre, Singapore

OTHER