Outcomes of Patients After Allo-HSCT With Decitabine and NAC

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

July 1, 2021

Primary Completion Date

July 1, 2025

Study Completion Date

December 1, 2025

Conditions
Engraft FailureRelapseGVHD
Interventions
DRUG

decitabine

Decitabine (20mg/m2 intravenously from day -10 to day -8 of conditional regimen)

DRUG

Acetylcysteine

Acetylcysteine: 1.2g twice a day, oral administration, from day -10 to day 365 after HSCT.

DRUG

Semustine

Semustine: 250 mg/m2/day on day -9.

DRUG

Cytarabine

Cytarabine: 2 g/m2 every 12 hours on day -8.

DRUG

Busulfan

Busulfan: 3.2mg/kg/day on day -7 to -5.

DRUG

Cyclophosphamide

Cyclophosphamide: 1.8g/m2/day on day -4 to -3.

DRUG

Cyclosporin A

Cyclosporin A: 3mg/kg/d from day -8.

DRUG

Anti-thymocyte globulin

Anti-thymocyte globulin (2mg/kg/d on day -5 to day -2) will be added for transplants with unrelated donor or HLA mismatched donor.

DRUG

Mycophenolate

Mycophenolate (500mg, oral, twice a day from day -8) will be added for transplants with unrelated donor or HLA mismatched donor.

All Listed Sponsors
lead

The First Affiliated Hospital of Soochow University

OTHER