100
Participants
Start Date
July 1, 2021
Primary Completion Date
July 1, 2025
Study Completion Date
December 1, 2025
decitabine
Decitabine (20mg/m2 intravenously from day -10 to day -8 of conditional regimen)
Acetylcysteine
Acetylcysteine: 1.2g twice a day, oral administration, from day -10 to day 365 after HSCT.
Semustine
Semustine: 250 mg/m2/day on day -9.
Cytarabine
Cytarabine: 2 g/m2 every 12 hours on day -8.
Busulfan
Busulfan: 3.2mg/kg/day on day -7 to -5.
Cyclophosphamide
Cyclophosphamide: 1.8g/m2/day on day -4 to -3.
Cyclosporin A
Cyclosporin A: 3mg/kg/d from day -8.
Anti-thymocyte globulin
Anti-thymocyte globulin (2mg/kg/d on day -5 to day -2) will be added for transplants with unrelated donor or HLA mismatched donor.
Mycophenolate
Mycophenolate (500mg, oral, twice a day from day -8) will be added for transplants with unrelated donor or HLA mismatched donor.
The First Affiliated Hospital of Soochow University
OTHER