Selinexor in Combination With Immunomodulator （Thalidomide/Pomalidomide/Lenalidomide）in RRMM

Selinexor (ATG-010# is a first-in-class, oral selective exportin 1 (XPO1) inhibitor (1,2). Selinexor functions by binding with and inhibiting the nuclear export protein XPO1 (also called CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus along with inhibition of translation of oncoprotein mRNAs. Selinexor 60mg/d QW

100mg/d, Po. on day1-28

PO,Lenalidomide 25mg once daily from D1-21

Pomalidomide will be given at 4mg once daily for 21 days in a 28-day cycle, PO.

Dexamethasone will be given at a dose of 40mg orally once a week for 4 weeks (D1,8,15,22).