Oregovomab in Combination With Bevacizumab Plus Chemo in BRCA Wild Type Platinum Sensitive Recurrent Ovarian Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

March 17, 2021

Primary Completion Date

April 30, 2024

Study Completion Date

December 31, 2025

Conditions
Ovarian Cancer by FIGO StageOvarian Cancer Stage IIIOvarian Cancer Stage IV
Interventions
BIOLOGICAL

Oregovomab

"Oregovomab will be administered on day1 cycle 1, 3, 5, and 9. A minimum of 3 patients will be enrolled into each cohort (2 mg or 1 mg).~2 mg (starting dose), dissolved in 2 mL of 0.9% Sodium Chloride Injection USP, then added to 50 mL of Sodium Chloride Injection USP infused over 20 ± 5 minutes"

DRUG

Bevacizumab

15mg/Kg Day 1 (every 21 days) until progression

DRUG

Paclitaxel

175 mg/m\^2, Day 1 x 6 cycles (every 21 days)

DRUG

Carboplatin

AUC 5 IV Day 1 x 6 cycles (every 21 days)

Trial Locations (6)

13496

RECRUITING

CHA Bundang Medical Center, Seongnam-si

41404

RECRUITING

Kyungpook National University Chilgok Hospital, Daegu

02841

RECRUITING

Korea Anam Hospital, Seoul

03722

RECRUITING

Severance Hospital, Seoul

05505

RECRUITING

Asan Medical Hospital, Seoul

06591

RECRUITING

Seoul St. Mary's Hospital, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Korean Cancer Study Group

OTHER

lead

CanariaBio Inc.

INDUSTRY