The GUARDIAN Trial - Induction Agent Sub-Study

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

6,254

Participants

Timeline

Start Date

July 25, 2021

Primary Completion Date

December 31, 2026

Study Completion Date

April 25, 2027

Conditions
Major Surgery
Interventions
PROCEDURE

Routine Blood Pressure Management

Routine blood pressure control.

PROCEDURE

Tight Blood Pressure Management

Tight blood pressure control.

DRUG

Etomidate Induction

Anesthetic induction with etomidate.

DRUG

Propofol Induction

Anesthetic induction with propofol.

Trial Locations (11)

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Fairview Hospital, Cleveland

44195

Cleveland Clinic Main Campus, Cleveland

68198

University of Nebraska Medical Center, Omaha

200025

Shanghai Ninth People's Hospital, Shanghai

Unknown

Beijing Shijitan Hospital, Capital Medical University, Beijing

Peking Union Medical College Hospital, Beijing

Shanghai Chest Hospital, Shanghai

West China Hospital, Sichuan

University of Thessaly, Larissa

National Defense College, Tokyo

All Listed Sponsors
lead

The University of Texas Health Science Center, Houston

OTHER