Vascular Impact of Dapagliflozin in CKD Patients (DAPAVASC)

Patients receive dapagliflozin 10mg tablets once a day during 12 weeks

Patients receive placebo tablets once a day during 12 weeks

impedance cardiography (PhysioFlow® PF-05 Lab1TM, Manatec Biomedical) is done for evaluation of cardiac function

Applanation tonometry will be done using SphygmoCor®, Hogimed) is done for evaluation of arterial stiffness

An arterial occlusion cuff will be placed on the forearm, and will be deflated to allow post-ischemic hyperemia with the continuous measurements of brachial artery diameter and blood flow velocity by high-resolution echotracking coupled to a Doppler system (ArtLab system®)

haemodynamics parameters will be evaluated using automatic oscillometric recorder