50
Participants
Start Date
June 9, 2021
Primary Completion Date
June 30, 2026
Study Completion Date
June 30, 2026
Codrituzumab
For Phase A (Dose Escalation), the starting dose (dose level 1) will be 10 mg/kg with 1 planned dose escalation to 20 mg/kg (dose level 2) if dose level 1 is determined to be safe and tolerable. Once a RP2D/MTD is identified in Phase A, then Phase B (hepatoblastoma expansion cohort) will open and allow for enrollment of up to 10 additional patients.For both phases, patients will receive codrituzumab IV once per week for a period of 21 days per cycle. Patients will be eligible for up to 25 cycles.
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Children's Healthcare of Atlanta (Data Collection Only), Atlanta
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Children's Hospital of Los Angeles (Data Collection Only), Los Angeles
RECRUITING
Dana Farber Cancer Institute (Data Collection Only), Boston
Collaborators (1)
Chugai Pharma USA
INDUSTRY
Memorial Sloan Kettering Cancer Center
OTHER