A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crises

PHASE3TerminatedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

December 9, 2021

Primary Completion Date

November 24, 2023

Study Completion Date

November 24, 2023

Conditions
Sickle Cell DiseaseVaso-occlusive CrisisVaso-occlusive Pain Episode in Sickle Cell Disease
Interventions
DRUG

Inclacumab

Inclacumab will be supplied in single use 10 mL vials at a concentration of 50 mg/mL. One vial contains 500 mg of inclacumab. This is a liquid concentrate for IV infusion.

DRUG

Placebo

Placebo will be supplied in single use 10 mL vials containing the same ingredients without the active drug. Placebo will be prepared as a liquid concentrate for IV infusion and administered in the same manner as active study drug.

Trial Locations (59)

123

Sultan Qaboos University Hospital, Muscat

10101

Matero Clinical Research Site,, Lusaka

University Teaching Hospital- Children's Hospital, Lusaka

10461

Jacobi Medical Center, The Bronx

14215

Erie County Medical Center, Buffalo

16128

Farmacia Interna Azienda Ospedaliero-Ente Ospedaliero Ospedali Galliera, Genova

S.S.D. Microcitemia, anemie congenite e dismetabolismo del ferro, Genova

23230

PPD Bioanalytical, Richmond

27705

Duke University Medical Center, Durham

27710

DUMC Investigational Drug Services Pharmacy, Durham

30100

International Cancer Institute, Eldoret

33343

Mersin Universitesi Tip Fakultesi Saglik Arastirma ve Uygulama Merkezi Hastanesi, Yenischir, Mersin

33607

St. Joseph's Hospital, Tampa

36604

Strada Patient Care Center, Mobile

University of South Alabama Children's and Women's Hospital, Mobile

University of South Alabama Mitchell Cancer Institute, Mobile

38105

St. Jude Children's Research Hospital, Memphis

40600

Kemri/Crdr, Siaya, Kemri Clinical Research Annex,, Kisumu

48109

University of Michigan Hospitals - Michigan Medicine, Ann Arbor

48202

Functional Fluidics, Inc., Detroit

72202

Arkansas Children's Hospital, Little Rock

80138

"DAI Materno-Infantile, UOC Clinica Pediatrica 1 Azienda Ospedaliera Universitaria Luigi Vanvitell", Napoli

UO di Farmacia Clinica, Dipartimento di Medicina Sperimentale Azienda Ospedaliera Universitaria, Napoli

"UOC Patologia Clinica e Molecolare Azienda Ospedaliera Universitaria Luigi Vanvitelli", Napoli

"UOC Radiologia Azienda Ospedaliera Universitaria Luigi Vanvitelli", Napoli

82943

Prince Mohammed bin Nasser Hospital, Jizan

85016

Phoenix Children's Hospital, Phoenix

89135

Alliance for Childhood Diseases dba Cure 4 The Kids Foundation, Las Vegas

92868

Children's Hospital of Orange County, Orange

93000

Hopital Avicenne, Bobigny

93053

Universitatsklinikum Regensburg Padiatrische Hamatologie, Onkologie und Stammzelltransplantation, Regensburg

94010

Hopital Henri Mondor, Créteil

94609

UCSF Benioff Children's Hospital, Oakland, Oakland

100254

Department of Pediatrics, College of Medicine, Lagos University Teaching Hospital, Lagos

460000

University of Nigeria Teaching Hospital, Enugu

540242

University of Calabar Teaching Hospital, Calabar

700223

Aminu Kano Teaching Hospital, Kano

800212

Barau Dikko Teaching Hospital/Kaduna State University, Kaduna

810107

Ahmadu Bello University Teaching Hospital (ABUTH), Zaria

900211

National Hospital Abuja, Abuja

902101

University of Abuja Teaching Hospital, Gwagwalada

41253-190

Instituto D'Or de Pesquisa e Ensino - Hospital São Rafael, Salvador

50070-460

Multihemo Servicos Medicos S/A, Recife

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

15090-000

Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto

08270-070

Casa de Saude Santa Marcelina, São Paulo

20211-030

Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti - HEMORIO, Rio de Janeiro

05403-000

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo -HCFMUSP, São Paulo

08270-120

CEPEC-Centro de Pesquisa Clinica, São Paulo

080020

Clinica de la Costa Ltda., Barranquilla

Organizacion Clinica Bonnadona Prevenir S.A.S., Barranquilla

00100

Kenya medical Research Institute-centre for Respiratory Disease Research, Nairobi

00200

Strathmore University Medical Center - Center for Research in Therapeutic Sciences(CREATES), Nairobi

Unknown

American University of Beirut Medical Center, Hamra

Nini Hospital, Tripoli

06230

Hacettepe University, Ankara

01250

Baskent University Hospital, Adana

01130

Acibadem Adana Hastanesi Cocuk Hematoloji Onkoloji, Adana

SE1 9RT

Guy's & Thomas' NHS Foundation Trust, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT04927247 - A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crises | Biotech Hunter | Biotech Hunter