Study to Evaluate the Efficacy and Safety of TT-00420 (Tinengotinib) in Cholangiocarcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

December 7, 2021

Primary Completion Date

February 28, 2024

Study Completion Date

February 28, 2024

Conditions
CholangiocarcinomaFGFR2 FusionFGFR2 Gene MutationFGFR1 AlterationFGFR3 Alteration
Interventions
DRUG

TT-00420

TT-00420 tablet, administered orally once daily

Trial Locations (32)

10029

Ruttenberg Treatment Center - Mount Sinai, New York

11794

Stony Brook University - Long Island Cancer Center, Stony Brook

12208

USOR Oncology Network- New York Oncology, New York

14203

Roswell Park Comprehensive Cancer Center, Buffalo

21250

University of Maryland - Marlene and Stewart Greenebaum Cancer Center, Baltimore

24014

USO Oncology Network-Oncology and Hematology Associates of Southwest Virginia, Inc., Roanoke

29425

Medical College of South Carolina, Charleston

33140

Mount Sinai Medical Center, Miami Beach

37203

Sarah Cannon Research Institute at Tennessee Oncology, Nashville

37920

The University of Tennessee Medical Center, Knoxville

44106

University Hospitals Seidman Cancer Center, Cleveland

45219

University of Cincinnati Cancer Institute, Cincinnati

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48202

Henry Ford Health Center, Detroit

53226

Medical College of Wisconsin, Milwaukee

53705

University of Wisconsin School of Medicine and Public Health, Madison

55905

Mayo Clinic, Rochester

75203

Methodist Dallas Medical Center, Dallas

75235

Parkland Health & Hospital System, Dallas

University of Texas Southwestern Harold C. Simmons Comprehensive Cancer Center, Dallas

77030

Houston Methodist Hospital - Outpatient Center, Houston

UT MD Anderson Cancer Center, Houston

89169

Comprehensive Cancer Center of Nevada, Las Vegas

90404

University of California, Los Angeles, School of Medicine, Santa Monica

91010

City of Hope, Duarte

97227

USO Oncology Network-Northwest Cancer Specialists, P.C., Portland

99508

Providence Cancer Center, Anchorage

80218-1237

USO Oncology Network- Rocky Mountain Cancer Centers, Denver

60637-1426

University of Chicago Medical Center - Duchossis Center for Advanced Medicine, Chicago

07932

Summit Medical Group - Florham Park Campus, Florham Park

75702-8363

USO Oncology Network-Texas Oncology, Tyler

23502-2824

USO Oncology Network-Virginia Oncology Associates - Brock Cancer Center - Norfolk, Norfolk

All Listed Sponsors
lead

TransThera Sciences (Nanjing), Inc.

INDUSTRY

NCT04919642 - Study to Evaluate the Efficacy and Safety of TT-00420 (Tinengotinib) in Cholangiocarcinoma | Biotech Hunter | Biotech Hunter