Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

224

Participants

Timeline

Start Date

July 10, 2024

Primary Completion Date

August 1, 2028

Study Completion Date

August 31, 2030

Conditions
Hearing LossHead and Neck Cancer
Interventions
OTHER

Placebo

Placebo will be formulated to also contain a white powder such that the atorvastatin and placebo are indistinguishable even if a capsule is opened.

DRUG

Atorvastatin

Subjects will be provided with atorvastatin (40 mg) or placebo to be taken daily by mouth or by feeding tube. The tablets may be taken whole or crushed according to patient swallowing capabilities and preference.

Trial Locations (4)

14642

NOT_YET_RECRUITING

Wilmot Cancer Institute at the University of Rochester Medical Center in New Yor, Rochester

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

21201

NOT_YET_RECRUITING

University of Maryland Medical Center, Baltimore

30322

NOT_YET_RECRUITING

Winship Cancer Institute at Emory University, Atlanta

All Listed Sponsors
lead

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH