A Study to Evaluate the One-way Interaction of Calcium Carbonate, Omeprazole, or Rifampin on ACP-196

PHASE1CompletedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

September 21, 2014

Primary Completion Date

October 16, 2014

Study Completion Date

October 16, 2014

Conditions
Healthy Participants
Interventions
DRUG

ACP-196

Participants will receive a single oral dose of ACP-196 100 mg capsule on Day 1 of Period 1 in Part 1, Part 2, and Part 3; and on Day 1 of Period 2 in Part 1, Day 5 of Period 2 in Part 2, and Day 1 and Day 9 of Period 2 in Part 3.

DRUG

Calcium carbonate

Participants will receive a single oral dose of calcium carbonate 1 g tablet on Day 1 of Period 2 in Part 1.

DRUG

Omeprazole

Participants will receive multiple oral doses of omeprazole 40 mg capsules QD for 5 consecutive days in Period 2 of Part 2.

DRUG

Rifampin

Participants will receive multiple oral doses of rifampin 600 mg capsule QD for 9 consecutive days in Period 2 of Part 3.

Trial Locations (1)

85283

Tempe

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Acerta Pharma BV

INDUSTRY