80
Participants
Start Date
June 29, 2021
Primary Completion Date
December 5, 2023
Study Completion Date
July 31, 2025
Rituximab
Rituximab 375 mg/m\^2 administered by IV infusion on Day 1 of every 21-day cycle
Cyclophosphamide
Cyclophosphamide 750mg/m\^2 administered by IV infusion on Day 1 of every 21-day cycle
Doxorubicin
Doxorubicin 50mg/m\^2 administered by IV infusion on Day 1 of every 21-day cycle
Vincristine
Vincristine 1.4mg/m\^2 administered by IV infusion on Day 1 of every 21-day cycle
Prednisolone
Prednisolone 100mg orally on Days 1-5 of every 21-day cycle
Glofitamab
Glofitamab will be administered by IV infusion as per the schedule specified in the respective arm
Polatuzumab vedotin
Polatuzumab 1.8mg/kg administered by IV infusion on Day 1 of every 21-day cycle
St Vincent's Public Hospital Sydney, Darlinghurst
Prince of Wales Hospital, Randwick
Concord Repatriation General Hospital, Camperdown
Calvary Mater Newcastle, Newcastle
Peter MacCallum Cancer Centre, Melbourne
St Vincent's Hospital Melbourne, Melbourne
Box Hill Hospital, Box Hill
Cabrini Hospital, Malvern
Barwon Health, Geelong
Royal Brisbane and Women's Hospital, Herston
Princess Alexander Hospital, Woolloongabba
Royal Adelaide Hospital, Adelaide
Sir Charles Gairdner Hospital, Nedlands
Alfred Hospital, Melbourne
Epworth Healthcare, Melbourne
Hoffmann-La Roche
INDUSTRY
Peter MacCallum Cancer Centre, Australia
OTHER