Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

April 15, 2021

Primary Completion Date

December 31, 2026

Study Completion Date

June 30, 2027

Conditions
Hepatocellular CarcinomaHepatocellular CancerColorectal CancerColorectal CarcinomaLiver Metastases
Interventions
BIOLOGICAL

Neoantigen Dendritic Cell Vaccine

10 doses of the vaccine will be administered via intra-dermal injection concurrently with adjuvant nivolumab.

DRUG

Nivolumab

9 doses of 240mg IV nivolumab as a 30 minutes infusion will be administered in combination with NA DC vaccine starting from the second vaccine dose. Upon completion of 10 doses of NA DC vaccine, 480mg IV nivolumab will be administered as a 30 minutes infusion for a maximum of 9 doses.

Trial Locations (1)

169690

RECRUITING

National Cancer Center Singapore, Singapore

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

National Cancer Centre, Singapore

OTHER

NCT04912765 - Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC | Biotech Hunter | Biotech Hunter