Osimertinib and Locally Ablative Radiotherapy in Patients With Synchronous Oligo-metastatic EGFR Mutant NSCLC (STEREO)

PHASE2TerminatedINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

August 4, 2022

Primary Completion Date

October 31, 2023

Study Completion Date

February 29, 2024

Conditions
NSCLC Stage IVEGFR Gene Mutation
Interventions
DRUG

Osimertinib

"Osimertinib is a Tyrosine Kinase Inhibitor (TKI). It is an irreversible inhibitor of Epidermal Growth Factor Receptors (EGFRs) harboring sensitising-mutations (EGFRm) and TKI-resistance mutation T790M.~The appropriate number of osimertinib tablets (80 mg or 40 mg if the dose is reduced due to toxicity) will be provided to patients to be self-administered at home."

RADIATION

Stereotactic Body Radiation Therapy (SBRT)

SBRT will be delivered using risk-adapted SBRT with a maximum of 5 SBRT fractions.

Trial Locations (18)

8091

Universitätsspital Zürich USZ, Zurich

10408

National Cancer Center, Goyang-si

28050

Centro Integral Oncologíco Clara Campal (CIOCC) HM Hospitales, Madrid

47014

IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola

Unknown

Instituto Europeo di Oncologia (IEO), Milan

AULSS2 Marca Trevigiana Treviso, Treviso

Leiden University Medical Center, Leiden

Medical University Gdansk, Gdansk

National University Hospital, Singapore

Severance Hospital, Yonsei University Health System, Sinchŏn-dong

Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona

Hospital Clínico de Valencia, Valencia

Sahlgrenska University Hospital, Gothenburg

Kantonsspital Aarau, Aarau

1006 BE

The Netherlands Cancer Institute Amsterdam, Amsterdam

03010

Hospital General de Alicante, Alicante

08035

Vall d'Hebron University Hospital, Barcelona

171 76

Karolinska Universitetssjukhuset Solna, Stockholm

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

ETOP IBCSG Partners Foundation

NETWORK