A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer After Progression on Standard of Care (SOC)

PHASE2CompletedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

November 8, 2021

Primary Completion Date

April 2, 2024

Study Completion Date

April 2, 2024

Conditions
Colorectal Cancer
Interventions
DRUG

RXC004

"RXC004 will be administered orally, 2 mg QD (Monotherapy); and 1.5 mg QD (Combination therapy)~Dose Formulation: 0.5 mg or 1 mg capsules."

BIOLOGICAL

Nivolumab

Nivolumab will be administered via IV infusion, 480 mg q4w.

BIOLOGICAL

Denosumab

"Denosumab will be administered via subcutaneous (SC) injection, 120 mg once every month.~Use: Prophylactic"

Trial Locations (22)

3722

Severance Hospital, Yonsei University Health System - Medical Oncology, Seoul

5505

Asan Medical Center - Oncology, Seoul

6351

Samsung Medical Center - Hematology-Oncology, Seoul

10408

National Cancer Center, Goyang-si

28041

Hospital Universitario 12 de Octubre, Madrid

41013

Hospital Universitario Virgen del Rocio, Seville

46250

Community Health Network Cancer Center North - Community Hospital Network, Indianapolis

77339

Lumi Research, Kingswood

89102

OptumCare Cancer Care, Las Vegas

95403

Providence Medical Foundation, Santa Rosa

77030-4000

UT MD Anderson Cancer Center, Houston

03080

Seoul National University Hospital, Seoul

08003

Hospital del Mar, Barcelona

08035

Hospital Universitario Vall d'Hebrón, Barcelona

08036

Hospital Clìnic de Barcelona, Barcelona

G12 0YN

Beatson West of Scotland Cancer Centre - Oncology, Glasgow

B152TH

Queen Elizabeth Hospital - Clinical Reasearch, Birmingham

NW1 2PG

University College of London (UCL), London

SW3 6JJ

The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital, London

CB2 0QQ

Christie Hospital, Manchester

OX3 7LJ

Oxford Cancer Centre, Oxford

SM25PT

The Royal Marsden Hospital (Surrey), Surrey Quays

All Listed Sponsors
lead

Redx Pharma Ltd

INDUSTRY

NCT04907539 - A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer After Progression on Standard of Care (SOC) | Biotech Hunter | Biotech Hunter