Ultra-Protective Lung Ventilation With Extracorporeal CO2 Removal for Moderate ARDS

NARecruitingINTERVENTIONAL
Enrollment

230

Participants

Timeline

Start Date

December 1, 2024

Primary Completion Date

December 31, 2026

Study Completion Date

March 31, 2027

Conditions
Acute Respiratory Distress Syndrome
Interventions
PROCEDURE

Ultraprotective ventilation with Extracorporeal CO2 removal

HLS5.0 Cardiohelp® (Getinge Cardiopulmonary Care, Rastatt, Germany): 1.3 m² polymethylpentene hollow fiber membrane oxygenator. The extracorporeal blood flow is in the range of 1000 to 1500 mL/min. Sweep gas (air or oxygen) is drawn through the hollow fibers by a vacuum pump, creating a diffusion gradient for gas exchange across the membrane.

PROCEDURE

Conventional protective ventilation

"Conventional lung protective mechanical ventilation, as described in the arm description (standardized ventilation)"

Trial Locations (1)

Unknown

RECRUITING

IRCCS AOUBO Policlinico di Sant'Orsola, Bologna

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Getinge Group

OTHER

lead

University of Bologna

OTHER

NCT04903262 - Ultra-Protective Lung Ventilation With Extracorporeal CO2 Removal for Moderate ARDS | Biotech Hunter | Biotech Hunter