230
Participants
Start Date
December 1, 2024
Primary Completion Date
December 31, 2026
Study Completion Date
March 31, 2027
Ultraprotective ventilation with Extracorporeal CO2 removal
HLS5.0 Cardiohelp® (Getinge Cardiopulmonary Care, Rastatt, Germany): 1.3 m² polymethylpentene hollow fiber membrane oxygenator. The extracorporeal blood flow is in the range of 1000 to 1500 mL/min. Sweep gas (air or oxygen) is drawn through the hollow fibers by a vacuum pump, creating a diffusion gradient for gas exchange across the membrane.
Conventional protective ventilation
"Conventional lung protective mechanical ventilation, as described in the arm description (standardized ventilation)"
RECRUITING
IRCCS AOUBO Policlinico di Sant'Orsola, Bologna
Collaborators (1)
Getinge Group
OTHER
University of Bologna
OTHER