Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

PHASE1RecruitingINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

December 10, 2021

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2026

Conditions
Viral Associated MalignanciesKaposi SarcomaEBV/KSHV-associated Lymphomas
Interventions
DRUG

Pomalidomide

Pomalidomide will be administered as an oral planned starting dose of 3 mg daily (dose escalation) or at an MTD of 4 mg (dose expansion). Pomalidomide will be given from day 1 to day 21 of each cycle.

DRUG

Nivolumab

Nivolumab will be administered IV at a dose of 480 mg at day one of each cycle, except for cycle one when it will be administered on day 8. One cycle equals 28 days

Trial Locations (1)

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH