A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH)

PHASE3CompletedINTERVENTIONAL
Enrollment

173

Participants

Timeline

Start Date

December 1, 2021

Primary Completion Date

July 26, 2024

Study Completion Date

February 18, 2025

Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG

Sotatercept

SC injection

OTHER

Placebo

Placebo-matched SC injection

Trial Locations (57)

161

La Sapienza-Università di Roma-Policlinico Umberto I ( Site 2402), Roma

1070

Hôpital Erasme ( Site 1402), Anderlecht

2010

St Vincent's Hospital Sydney ( Site 1102), Darlinghurst

2305

John Hunter Hospital ( Site 1101), New Lambton Heights

3000

UZ Leuven Campus Gasthuisberg ( Site 1401), Leuven

14080

Instituto Nacional De Cardiologia Dr. Ignacio Chavez ( Site 2503), Mexico City

20037

The George Washington University Medical Faculty Associates ( Site 1025), Washington D.C.

20123

Ospedale S. Giuseppe Multimedica ( Site 2403), Milan

27713

Duke University Medical Center ( Site 1026), Durham

28041

Hospital Universitario 12 de Octubre ( Site 1603), Madrid

29425

Medical University of South Carolina - PPDS ( Site 1003), Charleston

30342

Northside Hospital ( Site 1073), Atlanta

30625

Medizinische Hochschule Hannover ( Site 1505), Hanover

31059

Centre Hospitalier Universitaire de Toulouse. ( Site 1315), Toulouse

32224

Mayo Clinic Jacksonville - PPDS ( Site 1045), Jacksonville

32804

AdventHealth Medical Group Advanced Lung Disease ( Site 1058), Orlando

34362

Lady Davis Carmel Medical Center ( Site 1705), Haifa

35392

Universitaetsklinikum Giessen und Marburg GmbH ( Site 1512), Giessen

37909

Statcare Pulmonary Consultants - Knoxville ( Site 1031), Knoxville

48109

University of Michigan ( Site 1011), Ann Arbor

50937

Uniklinik Köln ( Site 1511), Cologne

52242

University Of Iowa Hospitals and Clinics ( Site 1050), Iowa City

53226

Medical College of Wisconsin - Froedtert Hospital ( Site 1051), Milwaukee

54511

CHU de Nancy - Hôpital de Brabois Adultes ( Site 1308), Vandœuvre-lès-Nancy

59037

CHRU Lille ( Site 1306), Lille

63110

Washington University School of Medicine ( Site 1022), St Louis

64460

"Hospital Universitario Dr. Jose Eleuterio Gonzalez ( Site 2504)", Monterrey

64718

Unidad de Investigación Clínica en Medicina, S.C ( Site 2505), Monterrey

66160

University of Kansas Medical Center ( Site 1020), Kansas City

66424

Universitätsklinikum des Saarlandes ( Site 1513), Homburg

67000

Hôpitaux Universitaires de Strasbourg ( Site 1307), Strasbourg

68105

University of Nebraska Medical Center ( Site 1053), Omaha

69126

Thoraxklinik-Heidelberg gGmbH ( Site 1509), Heidelberg

69500

Hôpital Louis Pradel ( Site 1317), Bron

75390

University Of Texas Southwestern Medical Center ( Site 1038), Dallas

80045

University of Colorado Hospital ( Site 1013), Aurora

80639

Krankenhaus Neuwittelsbach ( Site 1510), München

85013

Arizona Pulmonary Specialists ( Site 1010), Phoenix

86021

CHU de Poitiers ( Site 1316), Poitiers

87131

University of New Mexico Health Sciences Center ( Site 1048), Albuquerque

90095

David Geffen School of Medicine at UCLA ( Site 1068), Los Angeles

92037

University of California San Diego Medical Center ( Site 1002), San Diego

94118

University of California San Francisco ( Site 1019), San Francisco

94275

CHU Bicêtre ( Site 1304), Le Kremlin-Bicêtre

92868-2994

University of California Irvine ( Site 1086), Orange

02111

Tufts Medical Center - PPDS ( Site 1012), Boston

02115

Brigham and Women's Hospital ( Site 1014), Boston

14642-0001

University of Rochester Medical Center - PPDS ( Site 1039), Rochester

45267-0558

University of Cincinnati Medical Center ( Site 1035), Cincinnati

44103-3736

The Cleveland Clinic Foundation. ( Site 1065), Cleveland

T1Y 6J4

Peter Lougheed Centre ( Site 2102), Calgary

H3T 1E2

Jewish General Hospital ( Site 2103), Montreal

01307

Universitätsklinikum Carl Gustav Carus an der TU Dresden. ( Site 1501), Dresden

1081 HV

VU Medisch Centrum ( Site 2601), Amsterdam

CB23 3RE

Royal Papworth Hospital ( Site 1208), Cambridge

SW3 6JY

Royal Brompton Hospital ( Site 1206), London

W2 1NY

Imperial College Healthcare NHS Trust ( Site 1203), London

All Listed Sponsors
lead

Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA

INDUSTRY

NCT04896008 - A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH) | Biotech Hunter | Biotech Hunter