Toripalimab Plus FLOT in Locally Advanced Gastric Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

June 25, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2028

Conditions
ChemotherapyImmune Checkpoint InhibitorLocally Advanced Gastric Carcinoma
Interventions
DRUG

FLOT combined with toripalimab

Patients received FLOT combined with toripalimab on Day 3 every 3 weeks, for a total of 3 cycles, followed by surgical treatment. Postoperative adjuvant therapy was determined based on pathological results: if a pathological complete response (pCR) was achieved, patients received 2 additional cycles of the neoadjuvant regimen; if pCR was not achieved, patients were given 4 cycles of SOX combined with toripalimab postoperatively.

Trial Locations (1)

450008

RECRUITING

Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou

All Listed Sponsors
lead

Henan Cancer Hospital

OTHER_GOV