CAR-T Followed by Bispecific Antibodies

PHASE2RecruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

November 5, 2021

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2027

Conditions
Large B-cell LymphomaDLBCL - Diffuse Large B Cell Lymphoma
Interventions
DRUG

mosunetuzumab

1 mg IV on Cycle 1 Day 1; 2 mg IV Cycle 1 Day 8; 60 mg IV Cycle 1 Day 15; 60 mg IV on Cycle 2 Day 1 and then 30 mg IV every 21 days beginning Cycle 2 Day 1 through Cycle 17.

DRUG

glofitamab

2.5 mg IV Cycle 1 Day 8; 10 mg IV Cycle 1 Day 15 then 30 mg every 21 days beginning Cycle 2 Day 1 through Cycle 12

DRUG

obinutuzumab

1000 mg IV on Cycle 1 Day 1.

Trial Locations (2)

19104

RECRUITING

Abramson Cancer Center of the University of Pennsylvania, Philadelphia

68198

RECRUITING

University of Nebraska Medical Center, Omaha

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Abramson Cancer Center at Penn Medicine

OTHER