The GUARDIAN Trial

NARecruitingINTERVENTIONAL
Enrollment

6,254

Participants

Timeline

Start Date

July 25, 2021

Primary Completion Date

December 31, 2026

Study Completion Date

April 25, 2027

Conditions
Blood Pressure
Interventions
PROCEDURE

Tight blood pressure management

Norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg.

PROCEDURE

Routine blood pressure management

ACEIs, ARBs, and/or calcium channel blockers can be given the morning of surgery if deemed appropriate by the attending anesthesiologist. Intraoperative blood pressure will be managed per clinical routine.

Trial Locations (20)

27106

COMPLETED

Wake Forest University, Wake Forest

44109

RECRUITING

MetroHealth Medical Center, Cleveland

44111

COMPLETED

Cleveland Clinic Fairview Hospital, Cleveland

44195

COMPLETED

Cleveland Clinic Main Campus, Cleveland

68198

COMPLETED

University of Nebraska Medical Center, Omaha

77030

RECRUITING

The University of Texas Health Science Center at Houston, Houston

Unknown

RECRUITING

Beijing Shijitan Hospital, Capital Medical University, Beijing

RECRUITING

Peking Union Medical College Hospital, Beijing

RECRUITING

Peking University First Hospital, Beijing

RECRUITING

West China University Hospital, Chengdu

RECRUITING

Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong

RECRUITING

Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

RECRUITING

Shanghai Chest Hospital, Shanghai

RECRUITING

Shanghai Ninth People's Hospital, Shanghai

RECRUITING

The Affiliated Lianyungang Hospital of Xuzhou Medical University, Xuzhou

COMPLETED

University of Thessaly, Larissa

RECRUITING

IRCCS Regina Elena National Cancer Institute, Rome

RECRUITING

National Defense Medical College, Tokyo

RECRUITING

Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Bakırköy

RECRUITING

Konya City Hospital, Konya

All Listed Sponsors
lead

The University of Texas Health Science Center, Houston

OTHER