174
Participants
Start Date
September 15, 2021
Primary Completion Date
December 1, 2028
Study Completion Date
December 1, 2028
CC-220
CC-220 by mouth at the assigned dose starting on Day 1 for 14 consecutive days of the 21-day treatment cycle for 6 cycles of treatment.
Rituximab
Rituximab 375 mg/m2 on Day 1 by intravenous (IV) infusion or 1400 mg (SC) subcutaneous (from Cycle 2) of a 21-day treatment cycle for up to a total of 6 cycles
Cyclophosphamide
Cyclophosphamide 750mg/m2 on Day 1 by IV infusion of a 21-day treatment cycle for up to a total of 6 cycles
Doxorubicin
Doxorubicin 50 mg/m2 IV infusion on Day 1 of a 21-day treatment cycle for up to a total of 6 cycles
Vincristine
Vincristine 1.4 mg/m2 (maximum of 2.0 mg total) IV intravenous on Day 1 of a 21-day treatment cycle for up to a total of 6 cycles
Prednisone
Prednisone 100 mg PO on Days 1 through 5 of each 21-day treatment or 100mg IV on Day 1 is also acceptable for up to a total of 6 cycles
CC-99282
CC-99282 by mouth at the assigned dose starting on Day 1 for 7 consecutive days of the 21-day treatment cycle for 6 cycles of treatment.
Polatuzumab vedotin
Polatuzumab vedotin 1.8 mg/kg on Day 1 by intravenous (IV) infusion of a 21-day treatment cycle for up to a total of 6 cycles
Rituximab
Rituximab 375 mg/m2 on Day 1 by intravenous (IV) infusion of a 21-day treatment cycle for up to a total of 6 cycles
RECRUITING
Taichung Veterans General Hospital, Taichung
COMPLETED
Local Institution - 301, Seoul
COMPLETED
Local Institution - 501, Adelaide
RECRUITING
Evangelismos General Hospital of Athens, Athens
RECRUITING
Attikon University General Hospital, Athens
WITHDRAWN
Roswell Park Cancer Institute, Buffalo
WITHDRAWN
Local Institution - 703, Pátrai
WITHDRAWN
Local Institution - 204, Madrid
RECRUITING
H. Virgen de la Victoria, Málaga
WITHDRAWN
Mayo Clinic - Jacksonville, Jacksonville
RECRUITING
Mayo Clinic Jacksonville - PPDS, Jacksonville
RECRUITING
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca
RECRUITING
Local Institution - 403, Taichung
RECRUITING
Georgios Papanikolaou General Hospital of Thessaloniki, Thessaloniki
RECRUITING
University Of Kansas Medical Center, Kansas City
RECRUITING
University of Nebraska - Fred and Pamela Buffet Center, Omaha
RECRUITING
MD Anderson Cancer Center, Houston
RECRUITING
Mayo Clinic - Arizona, Scottsdale
RECRUITING
National Taiwan University Hospital, Taipei
RECRUITING
Mayo Clinic - Rochester, Rochester
COMPLETED
Local Institution - 503, Perth
WITHDRAWN
Local Institution - 502, Waratah
RECRUITING
"General Hospital of Athens Laiko", Athens
RECRUITING
Uniwersyteckie Centrum Kliniczne, Gdansk
RECRUITING
MCM Krakow - PRATIA - PPDS, Krakow
RECRUITING
Centrum Medyczne Pratia Poznan, Poznan
WITHDRAWN
Local Institution - 0706, Poznan
WITHDRAWN
Local Institution - UNK0706, Poznan
RECRUITING
SP ZOZ Szpital Uniwersytecki w Krakowie, Słomniki
RECRUITING
Local Institution - 602, Warsaw
COMPLETED
Local Institution - 604, Wroclaw
COMPLETED
Local Institution - 300, Seoul
COMPLETED
Local Institution - 302, Seoul
RECRUITING
Hospital Universitari Germans Trias i Pujol ICO Badalona, Barcelona
Lead Sponsor
Celgene
INDUSTRY