A Trial of a Peptide-based Group A Streptococcal (GAS) Vaccine Candidate in Healthy Individuals.

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

November 7, 2022

Primary Completion Date

May 12, 2025

Study Completion Date

May 12, 2025

Conditions
Group A Streptococcal Infection
Interventions
BIOLOGICAL

p*17-K4S2

Administer p\*17-K4S2 25 μg vaccine at 0, 3, and 6 weeks and evaluate the safety and antibody levels for a total of 6 months after the last injection. All vaccines will be administered intramuscularly

BIOLOGICAL

J8-K4S2

Administer a vaccination schedule of J8-K4S2 50μg vaccine at 0, 3, and 6 weeks and evaluate the safety and antibody levels for a total of 6 months after the last injection. All vaccines will be administered intramuscularly

BIOLOGICAL

Rabavert vaccine

Administer the standard Rabavert vaccine at 0, 3, and 6 weeks and evaluate the safety and antibody levels for a total of 6 months after the last injection. All vaccines will be administered intramuscularly. The Rabavert vaccine will be used as a control comparator as it has a similar approved dosing schedule to the investigational vaccines.

Trial Locations (1)

T6G 2B7

University of Alberta Hospital, Edmonton

All Listed Sponsors
collaborator

Griffith University

OTHER

lead

University of Alberta

OTHER

NCT04882514 - A Trial of a Peptide-based Group A Streptococcal (GAS) Vaccine Candidate in Healthy Individuals. | Biotech Hunter | Biotech Hunter