A Trial of a Peptide-based Group A Streptococcal (GAS) Vaccine Candidate in Healthy Individuals.

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

November 7, 2022

Primary Completion Date

May 12, 2025

Study Completion Date

May 12, 2025

Conditions
Group A Streptococcal Infection
Interventions
BIOLOGICAL

p*17-K4S2

Administer p\*17-K4S2 25 μg vaccine at 0, 3, and 6 weeks and evaluate the safety and antibody levels for a total of 6 months after the last injection. All vaccines will be administered intramuscularly

BIOLOGICAL

J8-K4S2

Administer a vaccination schedule of J8-K4S2 50μg vaccine at 0, 3, and 6 weeks and evaluate the safety and antibody levels for a total of 6 months after the last injection. All vaccines will be administered intramuscularly

BIOLOGICAL

Rabavert vaccine

Administer the standard Rabavert vaccine at 0, 3, and 6 weeks and evaluate the safety and antibody levels for a total of 6 months after the last injection. All vaccines will be administered intramuscularly. The Rabavert vaccine will be used as a control comparator as it has a similar approved dosing schedule to the investigational vaccines.

Trial Locations (1)

T6G 2B7

University of Alberta Hospital, Edmonton

All Listed Sponsors
collaborator

Griffith University

OTHER

lead

University of Alberta

OTHER