NCT04876807 - A Study to Evaluate the Effect of an Acidic Formulation of Acalabrutinib (ACP-196), Acidic Beverage, or Grapefruit Juice on the Pharmacokinetics (PK) of ACP-196 Alone and Coadministered With Omeprazole | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

January 28, 2016

Primary Completion Date

March 15, 2016

Study Completion Date

March 15, 2016

Conditions

Healthy Volunteers

Interventions

DRUG

ACP-196

In Parts 1, 2, and 3, participants will receive oral Dose 1 of ACP-196 (reference or acidic formulation as applicable) on Day 1, Day 3, Day 8, and Day 10.

DRUG

Omeprazole

Participants will receive omeprazole in all parts as: on Day 8 and Day 10 with water in Part 1; on Day 8 with water and on Day 10 with acidic beverage in Part 2; on Day 8 with water and on Day 10 with grapefruit juice in Part 3.

Trial Locations (1)

(402) 437-483

Laura Sterling, MD, MPH, Lincoln