A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial)

PHASE3CompletedINTERVENTIONAL
Enrollment

106

Participants

Timeline

Start Date

April 28, 2021

Primary Completion Date

November 21, 2024

Study Completion Date

November 21, 2024

Conditions
Diabetes Mellitus, Type 2Chronic Kidney Disease
Interventions
DRUG

Semaglutide

Semaglutide given subcutaneously (sc, under the skin) once weekly. Dose gradually increased over 8 weeks from 0.25 to 1.0 mg. The study will last for about 1 year.

DRUG

Placebo (Semaglutide)

Placebo (Semaglutide) given subcutaneously (sc, under the skin) once weekly. Dose gradually increased over 8 weeks from 0.25 to 1.0 mg. The study will last for about 1 year.

Trial Locations (31)

2100

Nefrologisk Klinik P 2132, Copenhagen

2730

Steno Diabetes Center Copenhagen, Herlev

4001

Maxwell Centre, Durban

4092

Precise Clinical Solutions (Pty) Ltd, Durban

7925

Prof Rayner_Division of Nephrology, Cape Town

20132

Istituto Scientifico San Raffaele, Milan

24127

Azienda Ospedaliera Papa Giovanni XXIII, Bergamo

31059

Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1, Toulouse

32804

Advent Health-Res Inst, Orlando

35128

Azienda Ospedaliera di Padova Clin.Med.3, Padua

38043

Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-2, Grenoble - Cédex 09

46010

Hospital Clinico Universitario de Valencia, Valencia

Hospital Clínico Universitario de Valencia, Valencia

51092

Centre Hospitalier Universitaire Reims-Hopital Maison Blanche, Reims

64111

Clinical Research Consultants, LLC, Kansas City

76230

Centre Hospitalier Universitaire de Rouen - Hopital de Bois Guillaume, Bois-Guillaume

77054

Prolato Clinical Research Cntr, Houston

78233

NE Clin Res of San Antonio, San Antonio

80045

UC Anschutz Medical Campus, Aurora

80054

Centre Hospitalier Universitaire Amiens Picardie-Site Sud, Amiens

90022

Academic Medical Research Institute, Los Angeles

91773

N America Res Inst - San Dimas, San Dimas

98195

Univ of Washington Med Ctr, Seattle

99204

Providence Medical Research Center, Spokane

M5G 2N2

UHN-Toronto General Hospital, Toronto

00189

Azienda Ospedaliero - Universitaria Sant'Andrea, Roma

26-600

"Centrum Medyczne Diabetika", Radom

04-749

Miedzyleski Szpital Specjalistyczny, Oddzial Nefrologiczny, Warsaw

41-800

Prywatny Gabinet Janusz Gumprecht, Zabrze

08035

Hospital Vall d'Hebron, Barcelona

08907

Hospital de Bellvitge, L'Hospitalet de Llobregat

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY