(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC

PHASE1TerminatedINTERVENTIONAL
Enrollment

177

Participants

Timeline

Start Date

June 29, 2021

Primary Completion Date

October 7, 2024

Study Completion Date

October 7, 2024

Conditions
Lung NeoplasmsCarcinoma, Non-Small-Cell LungRespiratory Tract NeoplasmsNeoplasmsNeoplasms by SiteLung DiseasesRespiratory Tract DiseaseCarcinoma, BronchogenicBronchial NeoplasmsAdenocarcinomaCarcinomaNeoplasms by Histologic TypeNeoplasms, Nerve TissueEGFR T790MEGFR C797SEGFR L858REGFR Gene MutationEGF-R Positive Non-Small Cell Lung CancerEGFR Exon 19 DeletionEGFR Mutation Resulting in Tyrosine Kinase Inhibitor ResistanceEGFR Activating MutationProtein Kinase InhibitorsAntineoplastic AgentsThoracic Neoplasms
Interventions
DRUG

BLU-945

Oral administration

DRUG

osimertinib

Osimertinib tablets for oral administration

Trial Locations (26)

10002

National Taiwan University Hospital, Taipei

10016

NYU Langone Health, Laura and Isaac Perlmutter Cancer Center, New York

10029

Icahn School of Medicine at Mount Sinai, New York

31059

Institut Claudius Regaud (IUCT-O) - Cancer Comprehensive Center, Toulouse

37203

Sarah Cannon Research Institute, Nashville

77030

The University of Texas MD Anderson Cancer Center, Houston

80045

University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora

90048

Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

92868

UC Irvine Health, Chao Family Comprehensive Cancer Center, Orange

94805

Institut Gustave Roussy - DITEP, Villejuif

169610

National Cancer Centre Singapore, Singapore

02114

Massachusetts General Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

M5G 2M9

Princess Margaret Cancer Centre, Toronto

277-8577

National Cancer Center Hospital East, Kashiwa

241-8515

Kanagawa Cancer Center, Yokohama

104-0045

National Cancer Center Hospital, Chuo Ku

1066 CX

The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam

03080

Seoul National University, Department of Internal Medicine, Seoul

03722

Yonsei Cancer Center, Severance Hospital, Yonsei University, Seoul

05505

Asan Medical Center, Department of Oncology, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

08035

Vall d'Hebron University Hospital, Oncology Department, Barcelona

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

All Listed Sponsors
lead

Blueprint Medicines Corporation

INDUSTRY