Neural Mechanisms of Immersive Virtual Reality in Chronic Pain

Participants will be assigned to an immersive VR environment.

Participants will be assigned to a sham VR environment without the immersive experience.

Participants will experience tonic pain tolerance tests without exposure to any environments.

"4mg of Naloxone will be administered (0.1 mL of 40 mg/ml naloxone solution given intranasally).~A random allocation sequence will be independently generated by the UM Pharmacy. The Principal investigator will call for each experiment."

"Intranasal Normal Saline (0.1 mL 0.9% sodium chloride) will be administered shortly before beginning the fMRI experiment.~A random allocation sequence will be independently generated by the UM Pharmacy. The Principal investigator will call for each experiment."

Participants will not be provided Naloxone or Saline.