18
Participants
Start Date
December 14, 2021
Primary Completion Date
January 31, 2027
Study Completion Date
December 31, 2027
N-803
N-803 will be given via subcutaneous injection at a dose of 15 mcg/kg every 4 weeks (1 week after starting treatment with the PDL-1 CAR-NK cells).
Pembrolizumab
Pembrolizumab 400 mg will be administered as a 30-minute IV infusion every 6 weeks. Pembrolizumab will be administered on the same day as the PD-L1 CAR-NK cells.
PD-L1 t-haNK
PD-L1 CAR NK cells (2x109) will be administered by IV infusion over approximately 30 minutes every week. After the week 6 treatment, these cells will be given every 2 weeks.
National Institutes of Health Clinical Center, Bethesda
National Cancer Institute (NCI)
NIH