NCT04844177View on ClinicalTrials.gov

Total Lymphoid Irradiation Pre-HSCT in Severe Congenital Neutropenia

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

April 14, 2021

Primary Completion Date

April 30, 2024

Study Completion Date

April 30, 2026

Conditions
Severe Congenital NeutropeniaGATA2 Deficiency
Interventions
OTHER

conditioning with TLI

"Total lymphoid irradiation 4 Gy (days -7, -6) in combination with:~* Fludarabine 150 mg/m2 (days-6, -5, -4, -3, -2)~* Cyclophosphamide 120 mg/kg (days -5, -4, -3)~* Thymoglogulin (Genzyme) 5 mg/kg (days -5, -4)~* Melphalan 180 mg/m2 (day -2)~* Rituximab 100 mg/m2 (day -1)~* Hematopoietic stem cell graft infusion after TCRab/CD19 depletion - day 0"

Trial Locations (1)

117198

HSCT department, Moscow

All Listed Sponsors
lead

Federal Research Institute of Pediatric Hematology, Oncology and Immunology

OTHER