Protocol Number: HJKC3-0003. Treatment Free Remission After Asciminib Based Therapy in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI Discontinuation

PHASE2RecruitingINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

November 11, 2021

Primary Completion Date

June 30, 2028

Study Completion Date

July 31, 2029

Conditions
Chronic Phase Chronic Myelogenous Leukemia
Interventions
DRUG

Asciminib 40 MG

40 mg by mouth (PO) when used with imatinib.

DRUG

Asciminib 40 MG Twice Daily

40 mg twice daily when used with nilotinib.

DRUG

Asciminib 80 MG daily

80 mg daily when used with dasatinib or taken alone.

DRUG

Imatinib

Maximum dose of 400 mg PO once daily.

DRUG

Nilotinib

Maximum dose of 300 mg twice daily.

DRUG

Dasatinib

Maximum dose of 100 mg PO once daily.

Trial Locations (4)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

48201

RECRUITING

The Barbara Ann Karmanos Cancer Institute, Detroit

53226

RECRUITING

Froedtert Hospital & the Medical College of Wisconsin, Milwaukee

84112

RECRUITING

Huntsman Cancer Institute, Salt Lake City

All Listed Sponsors
collaborator

H. Jean Khoury Cure CML Consortium

OTHER

lead

Medical College of Wisconsin

OTHER