Nemvaleukin Alfa Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Cutaneous or Mucosal Melanoma - ARTISTRY-6

PHASE2TerminatedINTERVENTIONAL
Enrollment

173

Participants

Timeline

Start Date

September 27, 2021

Primary Completion Date

May 8, 2025

Study Completion Date

May 8, 2025

Conditions
Cutaneous MelanomaMucosal Melanoma
Interventions
DRUG

Nemvaleukin Alfa Subcutaneous

Subcutaneous injection of nemvaleukin every 7 days

DRUG

Nemvaleukin Alfa Intravenous

Intravenous (IV) infusion over 30 minutes given daily for 5 consecutive days

DRUG

Nemvaleukin Alfa Intravenous Less Frequent Dosing

Intravenous (IV) infusion over 30 minutes twice every 21 days (Day 1 and Day 8 dosing of a 21 day cycle)

DRUG

Pembrolizumab

Cohort 4 only: 200mg IV pembrolizumab on Day 1 of a 21-day cycle

Trial Locations (41)

112

Taipei Veterans General Hospital, VGHTPE, Taipei

144

IRCCS Istituti Fisioterapici Ospitalieri, Roma

333

Chang Gung Memorial Hospital LinKou, Taoyuan District

2298

Calvary Mater Newcastle, Waratah

4224

John Flynn Private Hospital, Tugun

5011

The Queen Elizabeth Hospital, Woodville

8035

Hospital Universitario Vall d'Hebron, Barcelona

10016

NYU Laura and Isaac Perimutter Cancer Center, New York

10032

Columbia University Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

20133

Fondazione IRCC Istituto Nazionale dei Tumori, Milan

28007

Hospital General Universitario, Madrid

28223

Hospital Universitario Quiron Pozuelo, Madrid

29010

Hospital Regional de Málaga, Málaga

32224

Mayo Clinic, Jacksonville

32806

Orlando Health, Inc, Orlando

35015

Chungnam National University Hospital, Daejeon

35128

Veneto Oncology Institute, Padua

40018

Norton Cancer Center, Louisville

41404

Kyungpook National University Chilgok Hospital, Daegu

50009

Hospital Universitario Miguel Servet, Zaragoza

53100

Azienda Ospedaliera Universitaria Senese Policlinico Le Scotte, Siena

70124

Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari, Bari

75390

UT Southwestern Medical Center of Dallas, Dallas

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

90025

The Angeles Clinic and Research Institute, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

02114

Massachusetts General Hospital, Boston

M5G 1Z5

Princess Margaret Cancer Centre, Toronto

H2X 1R9

Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal

H4A 3J1

McGill University Health Center (MUHC), Montreal

06132

Ospedale S. Maria della Misericordia, Perugia

06591

The Catholic Univ. of Korea, Seoul St. Marys Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

06351

Samsung Medical Center, Gangam-gu

03080

Seoul National University Hospital, Jongno-gu

05505

Asan Medical Center, Songpa-Gu

08036

Hospital Clinic Barcelona, Barcelona

SW3 6JJ

Royal Marsden Hospital, London

M20 4BX

The Christie Hospital, Manchester

OX3 7LE

The Churchill Hospital, Oxford

Sponsors
All Listed Sponsors
lead

Mural Oncology, Inc

INDUSTRY