Neoadjuvant Treatment Modalities in Esophageal Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

2,000

Participants

Timeline

Start Date

January 1, 2002

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Esophageal CancerChemotherapy EffectChemoradiationSurgeryTargeted TherapyImmunotherapyEsophagogastric Juction Cancer
Interventions
DRUG

Platinum based chemotherapy

q1-3W according to physician's preference

DRUG

Paclitaxel based chemotherapy

q1-3W according to physician's preference

RADIATION

Radiotherpay

40-50Gy/1.8-2.2Gy/20-25f

PROCEDURE

Surgery

Radical esophagectomy

DRUG

Immunotherapy

Anti-PD-1/PD-L1 Antibody

DRUG

5-FU Analog based chemotherpay

W1-5 qW or d1-14, q3W according to physician's preference

DRUG

Nimotuzumab

200-400mg, d1,qW

Trial Locations (1)

100021

RECRUITING

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing

All Listed Sponsors
lead

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER