Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

2,000

Participants

Timeline

Start Date

January 1, 2002

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Esophagus CancerEsophagogastric Junction CancerChemoradiationTargeted TherapyImmunotherapyChemotherapy Effect
Interventions
RADIATION

Radiotherapy

50-66Gy/1.8-2.2Gy/25-30f

DRUG

Platinum based chemotherapy

q1-3W according to physician's preference

DRUG

Paclitaxel based chemotherapy

q1-3W according to physician's preference

DRUG

Immunotherapy

Anti-PD-1/PD-L1 Antibody

DRUG

5-FU Analog based chemotherapy

W1-5 qW or d1-14, q3W according to physician's preference

DRUG

Nimotuzumab

200-400mg, d1,qW

Trial Locations (5)

100021

RECRUITING

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing

210009

RECRUITING

Department of Radiation oncology, Jiangsu Cancer Hospital/Jiangsu Institute of Cancer Research/The affiliated Cancer Hospital of Nanjing Medical University, Nanjing

210029

RECRUITING

Department of Radiation oncology, Jiangsu Province Hospital/The First Affiliated Hospital with Nanjing Medical University, Nanjing

410031

RECRUITING

Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha

455001

RECRUITING

Department 4th of Radiation Oncology, Anyang Cancer Hospital, Anyang

All Listed Sponsors
lead

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER