A Study Evaluating Treatment Regimens Containing Vebicorvir (ABI-H0731) in Participants With Chronic Hepatitis B Infection

PHASE2TerminatedINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

May 7, 2021

Primary Completion Date

March 30, 2023

Study Completion Date

March 30, 2023

Conditions
Chronic Hepatitis B
Interventions
DRUG

VBR

VBR is an HBV core protein inhibitor. Participants will receive VBR 300 mg tablets orally once daily (QD).

DRUG

AB-729

AB-729 is a small interfering ribonucleic acid (siRNA) inhibitor of HBV. Participants will receive a 60-mg subcutaneous injection of AB-729 once every 8 weeks.

DRUG

SOC NrtI

Participants will receive their SOC NrtI (ETV, TDF or TAF) tablet orally as per approved package insert.

Trial Locations (20)

1010

Auckland Clinical Studies, Auckland

1407

Acibadem City Clinic Tokuda Hospital, Sofia

1431

Diagnostic Consultative Center Aleksandrovska, Sofia

University Multiprofile Hospital for Active Treatment St. Ivan Rilski, Sofia

2010

Saint Vincent's Hospital Sydney, Darlinghurst

2145

Westmead Hospital, Westmead

2170

Liverpool Hospital, Liverpool

2217

Saint George Hospital - Australia, Kogarah

3004

The Alfred Hospital, Melbourne

3011

Footscray Hospital, Footscray

3050

Melbourne Health, Parkville

6000

Nov Rehabilitatsionen Tsentar EOOD, Stara Zagora

6009

Sir Charles Gairdner Hospital, Nedlands

6021

Wellington Regional Hospital, Wellington

V6Z 2C7

Vancouver Infectious Disease Centre, Vancouver

V6Z 2K5

Pacific Gastroenterology Associates, Vancouver

N6A 2C2

University Hospital - London Health Sciences Centre, London

K1H 8L6

Ottawa Hospital Research Institute, Ottawa

M6H 3M1

Toronto Liver Centre, Toronto

G1V 4G2

Centre Hospitalier Université de Québec - Université Laval, Québec

Sponsors
All Listed Sponsors
collaborator

Arbutus Biopharma Corporation

INDUSTRY

lead

Assembly Biosciences

INDUSTRY