Study to Assess Efficacy and Safety of VIT-2763 (Vamifeport) in Subjects With Sickle Cell Disease

PHASE2CompletedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

November 18, 2021

Primary Completion Date

March 7, 2024

Study Completion Date

March 7, 2024

Conditions
Sickle Cell Disease
Interventions
DRUG

VIT-2763 120 mg

"Participants receive 2 capsules of VIT-2763 30 mg in the morning and in the evening, for 8 weeks.~Capsules are to be taken orally."

DRUG

VIT-2763 360 mg

"Participants receive 2 capsules of VIT-2763 60 mg in the morning, in the afternoon and in the evening for 8 weeks.~Capsules are to be taken orally."

DRUG

VIT-2763 240 mg

"Participants receive 2 capsules of VIT-2763 60 mg in the morning and in the evening, for 8 weeks.~Capsules are to be taken orally."

DRUG

Placebo BID

"Participants receive 2 capsules of placebo in the morning and in the evening, for 8 weeks.~Capsules are to be taken orally."

DRUG

Placebo TID

"Participants receive 2 capsules of Placebo in the morning, in the afternoon and in the evening, for 8 weeks.~Capsules are to be taken orally."

Trial Locations (22)

11527

Investigator Site 305, Athens

27834

Investigator Site 701, Greenville

29425

Investigator Site 711, Charleston

33023

Investigator Site 706, Hollywood

53226

Investigator Site 702, Milwaukee

60612

Investigator Site 703, Chicago

80045

Investigator Site 713, Aurora

90027

Investigator Site 708, Los Angeles

92700

Investigator Site 801, Colombes

690003

Investigator Site 802, Lyon

35233-2110

Investigator Site 709, Birmingham

GR-11527

Investigator site 301, Athens

Unknown

Investigator Site 302, Pátrai

Investigator Site 101, Baabda

Investigator Site 102, Beirut

Investigator Site 103, Tripoli

Investigator Site 601, London

Investigator Site 605, London

L9 7AL

Investigator Site 606, Liverpool

SE59RS

Investigator Site 603, London

W12 0HS

Investigator Site 608, London

M13 9WL

Investigator Site 607, Manchester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Fortrea

INDUSTRY

lead

Vifor (International) Inc.

INDUSTRY