NCT04815902View on ClinicalTrials.gov

Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

May 18, 2021

Primary Completion Date

February 1, 2025

Study Completion Date

June 1, 2025

Conditions
Osteoarthritis, Knee
Interventions
DRUG

Fisetin

Oral Fisetin 20 mg/kg taken for 10 days total.

DRUG

Losartan

12.5 mg oral Losartan taken for 30 days total.

DRUG

Placebo - Losartan

Losartan appearance-matched microcrystalline cellulose placebo. 12.5 taken for 30 days total.

DRUG

Placebo Fisetin

Fisetin appearance-matched microcrystalline cellulose placebo. 20 mg/kg taken for 10 days total.

Trial Locations (1)

81657

The Steadman Clinic, Vail

All Listed Sponsors
collaborator

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIH

lead

Steadman Philippon Research Institute

OTHER