Immunomodulation With Eltrombopag in ITP

PHASE2CompletedINTERVENTIONAL
Enrollment

2

Participants

Timeline

Start Date

September 1, 2022

Primary Completion Date

April 11, 2024

Study Completion Date

April 11, 2024

Conditions
Primary Immune Thrombocytopenia (ITP)
Interventions
DRUG

Eltrombopag (Revolade®)

Eltrombopag is a thrombopoietin receptor agonist (TPO-RA) indicated in patients with ITP refractory to first-line drugs or lasting more than 6 months. Administration of Eltrombopag (Revolade®), 50 mg PO, from day 5-140. Tapering over 1 week from day 141-148 with 50 mg every second day.

DRUG

standard therapy (without eltrombopag): HD-DXM

standard therapy (without eltrombopag): HD-DXM administered orally (40 mg) from day 1-4

Trial Locations (6)

4031

University Children's Hospital Basel (UKBB), Basel

University Hospital Basel, Division of Hematology, Basel

Unknown

Aarau Cantonal Hospital, Division of Hematology, Aarau

University Hospital Bern, Division of Hematology, Bern

Liestal Cantonal Hospital, Division of Hematology, Liestal

Lucerne Cantonal Hospital, Division of Hematology, Lucerne

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Stiftung zur Förderung medizinischer und biologischer Forschung

UNKNOWN

collaborator

Novartis Pharmaceuticals

INDUSTRY

collaborator

University of Erlangen-Nürnberg, Department of Biology

UNKNOWN

lead

University Children's Hospital Basel

OTHER