Targeting ATR in Soft-tissue Sarcomas

PHASE2RecruitingINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

February 9, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

December 31, 2027

Conditions
Leiomyosarcoma, Adult
Interventions
DRUG

Association of berzosertib with gemcitabine

"Gemcitabine will be administered by intravenous 30-minutes infusion on days 1 and 8 every 3 weeks, at a fixed dose of 1000 mg/m².~Berzosertib will be administered intravenously on days 2 and 9 every 3 weeks (210 mg/m²).~A treatment cycle consists of 3 weeks (i.e., 21 days) and will be administered during hospitalization."

DRUG

Gemcitabine

"Gemcitabine will be administered by intravenous 30-minutes infusion on days 1 and 8 every 3 weeks, at a fixed dose of 1000 mg/m².~A treatment cycle consists of 3 weeks (i.e., 21 days) and will be administered during hospitalization."

Trial Locations (6)

31059

RECRUITING

IUCT Oncopôle, Toulouse

33076

RECRUITING

Institut Bergonié, Bordeaux

44805

WITHDRAWN

Institut de Cancérologie de l'Ouest, Saint-Herblain

69008

RECRUITING

Centre Leon Berard, Lyon

86000

RECRUITING

CHU Poitiers, Poitiers

94805

RECRUITING

Institut Gustave Roussy, Villejuif

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

INDUSTRY

lead

Institut Bergonié

OTHER