VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

April 18, 2023

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Solid TumorRhabdomyosarcoma
Interventions
DRUG

Atezolizumab

Feasibility and RMS Cohorts: Administered at 15 mg/kg (max 1,200 mg) IV on Day 1 of each 21-day cycle

DRUG

Vincristine

Feasibility and RMS Cohorts: Administered at 1.5 mg/m\^2 (max 2 mg) IV on Day 1 of each 21-day cycle

DRUG

Irinotecan

Feasibility and RMS Cohorts: Administered at 50 mg/m2 IV on Days 1-5 of each 21-day cycle

DRUG

Temozolomide

Feasibility and RMS Cohorts: Administered at 100 mg/m\^2 (max 200 mg) IV or PO 1 hour before irinotecan injection on Days 1-5 if each 21-day cycle

Trial Locations (7)

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

45229

RECRUITING

Cincinnati Children's Hospital, Cincinnati

60611

RECRUITING

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

75235

RECRUITING

The University of Texas Southwestern Medical Center, Dallas

77030

RECRUITING

Texas Children's Hospital, Houston

98105

RECRUITING

Seattle Children's, Seattle

02115

NOT_YET_RECRUITING

Boston Children's Hospital, Boston

All Listed Sponsors
lead

University of Texas Southwestern Medical Center

OTHER