The COCOA-PAD II Trial

PHASE3RecruitingINTERVENTIONAL
Enrollment

190

Participants

Timeline

Start Date

November 19, 2021

Primary Completion Date

May 31, 2026

Study Completion Date

January 31, 2027

Conditions
Peripheral Artery Disease
Interventions
DRUG

cocoa flavanols

The cocoa flavanols intervention is manufactured by Mars Inc. Participants randomized to cocoa flavanols will take two capsules daily of cocoa flavanols. The two capsules of cocoa flavanols will contain approximately 500 mg of cocoa flavanols and appoximately 80 mg of (-)-epicatechin.

DRUG

placebo

The placebo intervention will be manufactured by Mars Inc. and will appear identical to the cocoa flavanols intervention. Participants will take two capsules daily of placebo. The placebo will be a cellulose based capsule and will not contain cocoa flavanols or (-)-epicatechin.

Trial Locations (3)

55455

RECRUITING

University of Minnesota, Minneapolis

60611

RECRUITING

Northwestern University, Chicago

60637

RECRUITING

University of Chicago, Chicago

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

collaborator

University of Minnesota

OTHER

collaborator

University of Chicago

OTHER

lead

Northwestern University

OTHER