CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial

NACompletedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

August 16, 2021

Primary Completion Date

March 29, 2023

Study Completion Date

March 29, 2023

Conditions
Infant, Newborn, DiseaseHypoxiaRespiratory Distress SyndromeBronchopulmonary Dysplasia
Interventions
PROCEDURE

Continuous positive airway pressure

After study entry, CPAP will be provided via mask or binasal prongs in order to have a relatively uniform CPAP delivery system among infants in the treatment group. Bubble CPAP will be preferred over other modes of CPAP delivery. A PEEP of 5 will be used for uniformity.

PROCEDURE

Nasal Cannula

After study entry, flow will be set to 0.5 L/kg with 1L maximum while on NC during the study period to reduce the risk of inadvertent PEEP with higher flows. Initial FiO2 can be titrated to achieve target saturations, and may be increased up to 100% while on NC.

Trial Locations (1)

35233

UAB Hospital, Birmingham

All Listed Sponsors
lead

University of Alabama at Birmingham

OTHER

NCT04792099 - CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial | Biotech Hunter | Biotech Hunter