Ixazomib-pomalidomide-dexamethasone as Second or Third-line Combination Treatment for Patients With Relapsed and Refractory Multiple Myeloma Previously Treated With Daratumumab, Lenalidomide and Bortezomib

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

March 25, 2021

Primary Completion Date

March 1, 2026

Study Completion Date

September 1, 2029

Conditions
Multiple Myeloma in RelapseRefractory Multiple Myeloma
Interventions
DRUG

ixazomib-pomalidomide-dexamethasone

"Cycles 1-3: during each 21-day cycle:~* ixazomib 3 mg on Days 1, 4, 8 and 11~* pomalidomide 4 mg on Days 1 through 14~* dexamethasone 20 mg on Days 1, 2, 8, 9, 15, 16~Cycle 4 and consequently: during each 28-day cycle:~* ixazomib 4 mg on Days 1, 8 and 15~* pomalidomide 4 mg on Days 1 through 21~* dexamethasone 20 mg on Days 1, 2, 8, 9, 15, 16, 22 and 23"

Trial Locations (7)

18101

Emek Medical Center, Afula

Unknown

Rambam Medical Center, Haifa

Hadassah Ein-Kerem Medical Center, Jerusalem

Shearei Zedek Medical Center, Jerusalem

Rabin Medical Center, Petah Tikva

Sheba Tel Hashomer, Ramat Gan

Tel Aviv Sourasky Medical Center, Tel Aviv

All Listed Sponsors
lead

Tel-Aviv Sourasky Medical Center

OTHER_GOV

NCT04790474 - Ixazomib-pomalidomide-dexamethasone as Second or Third-line Combination Treatment for Patients With Relapsed and Refractory Multiple Myeloma Previously Treated With Daratumumab, Lenalidomide and Bortezomib | Biotech Hunter | Biotech Hunter