OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosilicate in Heart Failure

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

September 1, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Heart FailureHyperkalemia
Interventions
DRUG

Sodium zirconium cyclosilicate

SZC is an approved drug in Sweden and subsidized for patients with chronic kidney disease in stages 3 to 5, with or without chronic heart failure, for whom treatment with Resonium is not suitable and for patients with chronic heart failure without con-comitant chronic kidney disease

OTHER

Placebo

Treatment with the same dose of placebo medicine as they would have received had they been treated with the interventional drug (SZC).

Trial Locations (2)

41650

Section of Cardiology, Sahlgrenska University Hospital-Östra Hospital, Gothenburg

Sahlgrenska University Hospital-Ostra Hospital, Gothenburg

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

Göteborg University

OTHER

lead

Michael Fu

OTHER