A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

PHASE3RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

July 1, 2022

Primary Completion Date

April 12, 2029

Study Completion Date

April 12, 2029

Conditions
Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Interventions
DRUG

Tolvaptan (OPC-41061)

Tolvaptan suspension will be administered orally or via nasogastric tube at doses of 0.15 mg/kg once daily in the AM, 0.30 mg/kg once daily in the AM, 0.5 mg/kg once daily in the AM, 0.75 mg/kg split dose (0.5 mg/kg AM and 0.25 mg/kg 8 hours later), and 1 mg/kg split dose (0.67 mg/kg AM and 0.33 mg/kg 8 hours later) based on age. Treatment duration is 2 years.

Trial Locations (18)

3000

RECRUITING

UZ Leuven, Leuven

9000

RECRUITING

Universitair Ziekenhuis Gent, Ghent

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21287

RECRUITING

Johns Hopkins Pediatric Specialty Clinic, Baltimore

30322

NOT_YET_RECRUITING

Emory University Hospital, Atlanta

41013

WITHDRAWN

Hospital Universitario Virgen del Rocio, Seville

44195

RECRUITING

Cleveland Clinic, Cleveland

50937

WITHDRAWN

Universitätsklinikum Köln, Cologne

55905

RECRUITING

Mayo Clinic - Rochester, Rochester

60611

RECRUITING

Northwestern University Feinberg School of Medicine - Ann & Robert H. Lurie Children's Hospital of Chicago - Neonatology, Chicago

84113

WITHDRAWN

Primary Children's Hospital, Salt Lake City

48109-5000

RECRUITING

C.S. Mott Children's Hospital, Ann Arbor

45229-3039

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

04-730

WITHDRAWN

"Instytut Pomnik - Centrum Zdrowia Dziecka", Warsaw

15-274

WITHDRAWN

Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Bialystok

08950

RECRUITING

Universitat de Barcelona - Hospital Sant Joan de Deu Barcelona (HSJDB), Esplugues de Llobregat

08035

RECRUITING

Hospital Universitari Vall D Hebron, Barcelona

WC1N 3JH

RECRUITING

Great Ormond Street Hospital for Children NHS Trust, London

All Listed Sponsors
lead

Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY