A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

PHASE3RecruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

March 29, 2021

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2030

Conditions
Diabetes Mellitus, Type 1Impaired Hypoglycemic AwarenessSevere Hypoglycemia
Interventions
BIOLOGICAL

VX-880

Infused into the hepatic portal vein.

Trial Locations (29)

15213

RECRUITING

University of Pittsburgh Medical Center Montefiore, Pittsburgh

19104

RECRUITING

Hospital of the University of Pennsylvania, Philadelphia

21287

RECRUITING

Johns Hopkins University, Baltimore

23298

RECRUITING

VCU Medical Center, Richmond, Richmond

33136

RECRUITING

UHealth Diabetes Research Institute, Miami

53792

RECRUITING

University of Wisconsin, Madison

60611

COMPLETED

Northwestern Organ Transplant Center, Chicago

60637

RECRUITING

University of Chicago, Chicago

75246

RECRUITING

Baylor Scott and White Research Institute, Dallas

91010

RECRUITING

City of Hope, Duarte

94143

RECRUITING

University of California San Francisco, San Francisco

02114

RECRUITING

Massachusetts General Hospital, Boston

Unknown

RECRUITING

University of Alberta, Edmonton, Edmonton

RECRUITING

McGill University Health Centre, Montreal

RECRUITING

Toronto General Hospital (TGH), Toronto

RECRUITING

Vancouver General Hospital, Vancouver

RECRUITING

CHU Lille, Lille

RECRUITING

Centre de recherche en Biomédecine de Strasbourg, Strasbourg

RECRUITING

Dresden Center for Islet Transplantation, Dresden

RECRUITING

IRCCS Ospedale San Raffaele, Milan

RECRUITING

Leiden University, Leiden

RECRUITING

Oslo University Hospital, Oslo

RECRUITING

King Abdullah International Medical Research Center (KAIMRC) - Riyadh - Endocrinology, Riyadh

RECRUITING

King Faisal Specialist Hospital & Research Centre - Riyadh - Endocrinology, Riyadh

RECRUITING

Hopiteaux Universitaires de Geneve, Geneva

RECRUITING

Churchill Hospital, Headington

RECRUITING

Royal Infirmary of Edinburgh, Edinburgh

RECRUITING

Cardiovascular, Metabolic Medicine and Sciences, King's College London, London

RECRUITING

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

All Listed Sponsors
lead

Vertex Pharmaceuticals Incorporated

INDUSTRY