Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

December 7, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2027

Conditions
Fanconi Anemia
Interventions
DRUG

JSP191

Participants will receive a single IV dose at start of conditioning

DEVICE

CliniMACS Prodigy System

The device used to remove the αβ+T cells from donor stem cell transplant before being given to the recipient

BIOLOGICAL

Depleted Stem Cell Transplant

TCRαβ+ T-cell/CD19+ B-cell depleted hematopoietic cells will be administered by IV after completion of conditioning regimen.

BIOLOGICAL

Rabbit Anti-Thymoglobulin (rATG)

3 consecutive daily doses of rATG will be given by IV during conditioning

DRUG

Cyclophosphamide

4 consecutive daily doses of cyclophosphamid will be given by IV during conditioning

DRUG

Fludarabine

4 consecutive daily doses of fludarabine will be given by IV during conditioning

DRUG

Rituximab

1 dose of rituximab will be given at the end of conditioning

Trial Locations (1)

94305

RECRUITING

Stanford University, Stanford

All Listed Sponsors
lead

Porteus, Matthew, MD

OTHER