12
Participants
Start Date
December 7, 2021
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2027
JSP191
Participants will receive a single IV dose at start of conditioning
CliniMACS Prodigy System
The device used to remove the αβ+T cells from donor stem cell transplant before being given to the recipient
Depleted Stem Cell Transplant
TCRαβ+ T-cell/CD19+ B-cell depleted hematopoietic cells will be administered by IV after completion of conditioning regimen.
Rabbit Anti-Thymoglobulin (rATG)
3 consecutive daily doses of rATG will be given by IV during conditioning
Cyclophosphamide
4 consecutive daily doses of cyclophosphamid will be given by IV during conditioning
Fludarabine
4 consecutive daily doses of fludarabine will be given by IV during conditioning
Rituximab
1 dose of rituximab will be given at the end of conditioning
RECRUITING
Stanford University, Stanford
Porteus, Matthew, MD
OTHER