Effect of RYGB on Alpha- and Beta Cell Function and Sensitivity to Incretins in Patients With Type 2 Diabetes

NACompletedINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

January 31, 2015

Primary Completion Date

January 31, 2022

Study Completion Date

March 31, 2022

Conditions
Type2 DiabetesObesity, Morbid
Interventions
DIAGNOSTIC_TEST

Oral Glucose Tolerance Test

Standard test of glucose tolerance with ingestion of 75 g glucose followed by blood sampling.

DIAGNOSTIC_TEST

Hyperglycemic clamp with infusion of saline, GLP-1 or GIP

"Blood glucose kept at 15 mmol/L via iv 20% glucose infusions.~Primed co-infusion of either:~* Saline~* GLP-1 (Prime dose 6 pmol/kg, infusion 1 pmol/kg/min)~* GIP (Prime dose 3 pmol/kg, infusion 1.5 pmol/kg/min)."

Trial Locations (1)

Unknown

Hvidovre University Hospital, Hvidovre

All Listed Sponsors
collaborator

University of Copenhagen

OTHER

lead

Hvidovre University Hospital

OTHER

NCT04782999 - Effect of RYGB on Alpha- and Beta Cell Function and Sensitivity to Incretins in Patients With Type 2 Diabetes | Biotech Hunter | Biotech Hunter